Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. Location: 49 → 116 IlGF IlGF, insulin_like growth factors specific to vertebrates. Variants 3 and 5 both encode the same isoform (3). Status: REVIEWED Description Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in a protein (isoform 3) with a novel C-terminus, compared to isoform 1. See identical proteins and their annotated locations for NP_001104755.1 Location: 33 → 100 IlGF insulin_like growth factors specific to vertebrates. This isoform (2) may undergo proteolytic processing similar to isoform 1. These differences cause translation initiation from a distinct start codon and result in an isoform (2) with novel N- and C-termini, compared to isoform 1. Status: REVIEWED Description Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. See identical proteins and their annotated locations for NP_001104754.1 Status: REVIEWED Description Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). See identical proteins and their annotated locations for NP_001104753.1 Location: 49 → 116 IlGF insulin_like growth factors specific to vertebrates. Variants 4 and 7 both encode the same isoform (4). Status: REVIEWED Description Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. See identical proteins and their annotated locations for NP_000609.1 NM_000618.5 → NP_000609.1 insulin-like growth factor I isoform 4 preproprotein NG_011713.1 RefSeqGene Range 5038.89727 Download GenBank, FASTA, Sequence Viewer (Graphics) This section to the one reported in Genomic regions, Identify version mismatches by comparing the version of the RefSeq in These reference sequences are curated independently of the genomeĪnnotation cycle, so their versions may not match the RefSeq versions in the current These reference sequences exist independently of genome builds. Expression Broad expression in endometrium (RPKM 7.0), fat (RPKM 6.3) and 18 other tissues See more Orthologs mouse all NEW Try the new Gene table Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. Defects in this gene are a cause of insulin-like growth factor I deficiency. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Full Name insulin like growth factor 1 provided by HGNC Primary source HGNC:HGNC:5464 See related Ensembl:ENSG00000017427 MIM:147440 AllianceGenome:HGNC:5464 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as IGF MGF IGFI IGF-I Summary The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development.
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